![]() ![]() Cushing syndrome can also be caused by a tumor of the adrenal gland producing too much cortisol. This is the most common cause of Cushing syndrome. If the ACH tumor is in the pituitary gland, this is referred to as Cushing disease. This can be caused by a tumor producing too much ACTH, to stimulate the adrenal production of cortisol. ![]() If it's high for too long, it can cause symptoms and can lead to serious problems, such as diabetes, high blood pressure, depression, and osteoporosis.Ĭushing syndrome refers to a situation where there is too much cortisol. If something upsets this system, your cortisol level can get too high. ACTH triggers the adrenal glands, which sit above the kidneys, to release cortisol. CRH tells the pituitary gland, located beneath the brain, to make a hormone called ACTH. When your cortisol level gets low, a part of the brain called the hypothalamus releases a hormone called CRH. Normally, your body keeps the level of cortisol in balance through a complex system that involves three glands: hypothalamus, pituitary and adrenal glands. But it affects almost every area of your body. Cortisol is especially important in controlling blood pressure and metabolism. Cushing's syndrome is a rare problem that happens when you have too much of the hormone cortisol in your body.
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